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Genomic consequences of stress and aging

I'm currently a Postdoctoral Fellow (NIH Kirschstein) in Evolutionary Anthropology at Duke University. My research is focused on the genomic consequences of stress and aging in nonhuman primate models, particularly the effects on immune gene regulation. My research uses single-cell genomics to understand how chronic social stress causes accelerated aging in the rhesus macaque model.

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PUBLICATIONS

 

PEER-REVIEWED PUBLICATIONS

Sanz, J., Maurizio, P.L., Snyder-Mackler, N., Simons, N.D., Voyles, T., Kohn, J., Michopoulos, V., Wilson, M., Tung, J. and Barreiro, L.B. (2019). Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques. (Proceedings of the National Academy of Sciences USA - in press)

Simons, N.D. & Tung, J. (2019) Social status and gene regulation: conservation and context-dependence in primates. Trends in Cognitive Sciences 23 (9): 9-11.

Simons, N.D., Eick, G.N., Ruiz-Lopez, M.J., Hyeroba, D., Omeja, P.A., Weny, G., Chapman, C.A., Goldberg, T.L., Zheng, H.Q., Shankar, A., Switzer, W.M., Sterner, K.N., Ting, N. (2019). Genome-wide patterns of gene expression in a wild primate indicate species-specific mechanisms associated with tolerance to natural simian immunodeficiency virus infection. Genome Biology and Evolution 11(6): 1630-1643.

SIMONS, N.D., EICK, G., RUIZ-LOPEZ, M.J., CHAPMAN, C.A., GOLDBERG, T.L., TING, N., STERNER, K.N. (2017). CIS-REGULATORY EVOLUTION IN A WILD PRIMATE: INFECTION-ASSOCIATED GENETIC VARIATION DRIVES DIFFERENTIAL EXPRESSION OF MHC-DQA1 IN-VITRO. MOLECULAR ECOLOGY: DOI:10.1111/MEC.14221.

SIMONS, N.D., RUIZ-LOPEZ, M.J., CHAPMAN, C.A., GOLDBERG, T.L., KARL, J.A., WISEMAN, R.W., BOHN, P.S., O’CONNOR, D.H., TING, N. (2016). RAPID HAPLOTYPE IDENTIFICATION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I USING DEEP SEQUENCING IN AN ENDANGERED OLD WORLD MONKEY. CONSERVATION GENETIC RESOURCES 8(1): 23-26.

GHAI, R.R., SIMONS, N.D., CHAPMAN, C.A., OMEJA, P.A., DAVIES, T.J., TING, N., GOLDBERG, T.L. (2014). HIDDEN POPULATION STRUCTURE AND CROSS-SPECIES TRANSMISSION OF WHIPWORMS (TRICHURIS SP.) IN HUMANS AND NON-HUMAN PRIMATES IN UGANDA. PLOS NEGLECTED TROPICAL DISEASES 8(10): E3256.

SIMONS, N.D., WAGNER, R.S., LORENZ, J.G. (2013). GENETIC DIVERSITY OF NORTH AMERICAN CAPTIVE WESTERN LOWLAND GORILLAS (GORILLA GORILLA GORILLA). ECOLOGY AND EVOLUTION 3: 80-88.

SIMONS, N.D., LORENZ, J.G., SHEERAN, L.K., LI, J., XIA, D., WAGNER, R.S. (2012). NONINVASIVE SALIVA COLLECTION FOR DNA ANALYSES FROM FREE-RANGING TIBETAN MACAQUES (MACACA THIBETANA). AMERICAN JOURNAL OF PRIMATOLOGY 74: 1064–1070.

NON PEER-REVIEWED PUBLICATIONS

SIMONS, N.D. (2015). CONCEPTUAL BREAKTHROUGHS IN EVOLUTIONARY GENETICS: A BRIEF HISTORY OF SHIFTING PARADIGMS. BY JOHN AVISE. 184 PP. WALTHAM, MA: ACADEMIC PRESS. AMERICAN JOURNAL OF HUMAN BIOLOGY, 27: 231–232.

WINTERS, S., DUNAYER, E.S., PETERSDORF, M., SIMONS, N.D., & TINSMAN, J. (2015). PRIMATOLOGY AND CONSERVATION IN HANOI, VIETNAM. EVOLUTIONARY ANTHROPOLOGY 23: 201-204.

 
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023 Biological Sciences 125 Science Drive, Durham, NC 27708 noah.simons@duke.edu       458-205-9256